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M94A3002.TXT
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1994-10-25
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Document 3002
DOCN M94A3002
TI Oral non-Hodgkin's lymphoma (ONHL) in 7 HIV-positive homosexual males.
DT 9412
AU Lozada-Nur F; Silverman S; Univ. of Calif., S.F.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):176 (abstract no. PB0131). Unique
Identifier : AIDSLINE ICA10/94369573
AB Non-Hodgkin's lymphoma (NHL) has emerged as a major sequela of HIV
infection. As patient life expectancy increases due to early
intervention with multiple drug therapies for HIV infection, there has
been a significant increase in the occurrence of NHL and ONHL.
Recognition is difficult since ONHL can appear similar to mycotic
infections, dental infections and salivary gland tumors. ONHL is very
aggressive, therefore, early diagnosis and treatment is important. Our
cases illustrate the clinical presentation and treatment approach in
seven patients with ONHL. Patient characteristics: age at onset (35-55);
the maxilla was the most common site (6 out of 7); all patients
experienced severe pain; all patients had received therapy with AZT from
9 to 60 months; all patients had oral candidiasis. Aggressive multiple
cytotoxic drug therapy was the standard form of treatment. Common side
effects were fatigue, nausea, weight loss, weakness and neutropenia.
Radiation therapy for ONHL was added in 2 patients. Survival times
ranged from 5 to 18 months. This is the largest reported series of ONHL.
DE Adult Antineoplastic Agents, Combined/THERAPEUTIC USE Combined
Modality Therapy Follow-Up Studies *Homosexuality Human HIV
Seropositivity/*DIAGNOSIS/DRUG THERAPY/MORTALITY Lymphoma,
AIDS-Related/*DIAGNOSIS/DRUG THERAPY/MORTALITY Male Middle Age Mouth
Neoplasms/*DIAGNOSIS/DRUG THERAPY/MORTALITY Survival Rate
Zidovudine/THERAPEUTIC USE MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).